Mini-Reviews in Medicinal Chemistry

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Chalcones and their Potential Role in Inflammation

Author(s): C. Kontogiorgis, M. Mantzanidou and D. Hadjipavlou-Litina

Affiliation: Aristotle University of Thessaloniki, School of Pharmacy, Department of Pharmaceutical Chemistry, 54124, Greece.

Abstract:

Chalcones are a group of phenolic compounds which possess a wide variety of cytoprotective and modulatory functions. They have been shown to possess antioxidant, oxygen scavenging and anti-inflammatory properties in a variety of experimental systems and can trigger the intracellular cascade of protective pathways offering a promising stratagem for therapeutic applications. In this research we will review the anti-inflammatory effect of chalcone derivatives and new approaches.

Keywords: Natural/synthetic chalcones, inflammation, anti-inflammatories, antioxidants

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Article Details

VOLUME: 8
ISSUE: 12
Page: [1224 - 1242]
Pages: 19
DOI: 10.2174/138955708786141034
Price: $58