Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Concerted Action of Metals and Macromolecular Crowding on the Fibrillation of α-Synuclein

Author(s): Larissa A. Munishkina, Anthony L. Fink, Vladimir N. Uversky.

Abstract:

Certain metals lead to increased risk of Parkinsons disease (PD) and the aggregation of α-synuclein is implicated in the PD pathology. Although α-synuclein fibrillation has been extensively studied in dilute solutions in vitro, the intracellular environment is highly crowded. We are showing here that certain metals cause a significant acceleration of α-synuclein fibrillation in the presence of high concentrations of various macromolecules mostly through decreasing the fibrillation lagtime. The faster fibrillation in crowded environments in the presence of heavy metals suggests a simple molecular basis for the observed elevated risk of PD due to exposure to metals.

Keywords: Parkinson's disease, α-synuclein, crowding, fibrillation, aggregation, metals

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Article Details

VOLUME: 15
ISSUE: 10
Year: 2008
Page: [1079 - 1085]
Pages: 7
DOI: 10.2174/092986608786071102
Price: $58