Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL


Concerted Action of Metals and Macromolecular Crowding on the Fibrillation of α-Synuclein

Author(s): Larissa A. Munishkina, Anthony L. Fink, Vladimir N. Uversky.


Certain metals lead to increased risk of Parkinsons disease (PD) and the aggregation of α-synuclein is implicated in the PD pathology. Although α-synuclein fibrillation has been extensively studied in dilute solutions in vitro, the intracellular environment is highly crowded. We are showing here that certain metals cause a significant acceleration of α-synuclein fibrillation in the presence of high concentrations of various macromolecules mostly through decreasing the fibrillation lagtime. The faster fibrillation in crowded environments in the presence of heavy metals suggests a simple molecular basis for the observed elevated risk of PD due to exposure to metals.

Keywords: Parkinson's disease, α-synuclein, crowding, fibrillation, aggregation, metals

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Article Details

Year: 2008
Page: [1079 - 1085]
Pages: 7
DOI: 10.2174/092986608786071102
Price: $58