Efficient Cleavage of Bid and Procaspase-7 by Caspase-2 at Lower pH

Author(s): Pratap Karki, Giri Raj Dahal, Song Yub Shin, Jung Sup Lee, Byungyun Cho, Il-Seon Park.

Journal Name: Protein & Peptide Letters

Volume 15 , Issue 10 , 2008

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Abstract:

The activity of caspase-2 was examined under varying biochemical conditions with the synthetic and protein substrates, Bid and procaspase-7. The results indicate that it was largely influenced by pH which might be one reason behind the inconsistency for the cleavage of its established substrates during caspase-2-induced apoptosis.

Keywords: Caspase-2, caspase-8, pH, salt, Bid, procaspase-7

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Article Details

VOLUME: 15
ISSUE: 10
Year: 2008
Page: [1044 - 1049]
Pages: 6
DOI: 10.2174/092986608786071193
Price: $58

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