An Efficient Synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione by the Michael Condensation Under Ultrasound Irradiation in Aqueous and Organic Two Phase in the Presence of Phase-Transfer Catalyst

Author(s): Ji-Tai Li, Xin-Li Zhai, Zhi-Ping Lin, Xiao-Hui Zhang.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 7 , 2008

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Abstract:

Improved synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione via double Michael condensation of 1,5- bisaryl-1,4-pentadien-3-one with cyclohexanone was carried out in 51-96% yields for 3-12 h in CH2Cl2-H2O in the presence of phase-transfer catalyst under ultrasound irradiation. In comparison with reported methods, the main advantages of the present procedure are shorter reaction time and higher yields.

Keywords: 7,11-Diarylspiro[5.5]undecane-1, 9-dione, synthesis, ultrasound irradiation, Michael condensation, phase-transfer catalysis

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Article Details

VOLUME: 5
ISSUE: 7
Year: 2008
Page: [579 - 582]
Pages: 4
DOI: 10.2174/157017808785982103
Price: $65

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