Novel Microwave-Assisted One-Pot Synthesis of Heterocycle Phosphor Esters and Cyclic Oxophospholes with Antibiotic Activity

Author(s): Wafaa M. Abdou, Abeer A. Shaddy.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 7 , 2008

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Abstract:

Reactions of 5,6-di-(2`-furyl)-3-oxo-2,3-dihydropyridazin-4-carbonitrile (1) with Wittig-Horner reagents were investigated under microwave irradiation, and the effect of basic catalysis. The methodology afforded moderate to high yields of fused heterocycles bearing a phosphonate ester and / or phosphor-containing fused heterocycles. Bioassay results showed that the antibiotic activity of the new synthesized phosphorus compounds is significantly high when compared to available Streptomycin and Mycostatin (standard).

Keywords: α, β-Unsaturated carbonitriles, Phosphonyl carbanions, Fused heterocycle phosphonates, Cyclic oxophospholes

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Article Details

VOLUME: 5
ISSUE: 7
Year: 2008
Page: [569 - 575]
Pages: 7
DOI: 10.2174/157017808785982220
Price: $65

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