An Efficient Synthesis of 2,3-Diaryl-2-azabicyclooctanones Via BiCl3- Catalysed Three-Component aza Diels-Alder Reaction

Author(s): Luis Astudillo S., Gabriel A. Vallejos, Nestor Correa, Margarita Gutierrez C., Walesca de la Guarda, Vladimir V. Kouznetsov.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 7 , 2008

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Abstract:

The first three-component coupling reactions between various anilines (1), benzaldehydes (2), and cyclohexen- 2-one (3) were performed under mild conditions (acetonitrile, room temperature, 14 h) in the presence of 20 mol % BiCl3 to obtain new 2,3-diaryl-2-aza[2.2.2]octan-5-ones (4,5) with interesting acetylcholinesterase inhibitory properties.

Keywords: 2,3-Diaryl-2-azabicyclo[2.2.2]octan-5-one, catalysed three-component aza Diels-Alder reaction, acetylcholinesterase inhibitors

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Article Details

VOLUME: 5
ISSUE: 7
Year: 2008
Page: [559 - 562]
Pages: 4
DOI: 10.2174/157017808785982301
Price: $65

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