A Novel Three-Component Reaction of Dibenzylamine and an Aromatic Aldehyde with an Alkyl Isocyanide in the Presence of Silica Gel: An Efficient Route for the One-Pot Synthesis of Sterically Congested 2-(Dibenzylamino)-2-Aryl Acetamide Derivatives

Author(s): Ebrahim Ahmadi, Amir T. Mahyari, Ali Ramazani, Mehdi N. Haghighi.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 7 , 2008

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Addition of an isocyanide to an iminium ion intermediate that forms from the reaction between an aromatic aldehyde and dibenzylamine, leads to formation of sterically congested 2-(dibenzylamino)-2-aryl acetamide derivatives in the presence of silica gel powder.

Keywords: Silica gel, multicomponent reaction, isocyanide, aldehyde, secondary amine, iminium ion

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Article Details

Year: 2008
Page: [540 - 543]
Pages: 4
DOI: 10.2174/157017808785982158
Price: $65

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