Synthesis of a New (+)-Catechin-Derived Compound: 8-Vinylcatechin

Author(s): Luis Cruz, Enrique Borges, Artur M.S. Silva, Nuno Mateus, Victor de Freitas.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 7 , 2008

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A strategy for the synthesis of 8-vinylcatechin was developed, which involves (+)-catechin silylation with TBDMS-Cl, followed by bromination with NBS, a cross-coupling Suzuki reaction with vinylboronic acid pinacol ester and cleavage of TBDMS groups with TBAF, affording the 8-vinylcatechin.

Keywords: (+)-Catechin, silylation, bromination, Suzuki coupling, desilylation, 8-vinylcatechin

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Article Details

Year: 2008
Page: [530 - 536]
Pages: 7
DOI: 10.2174/157017808785982211
Price: $65

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