Facile and Efficient Synthesis of Ethyl 3-Oxo-5-arylthiopentanoates, the Precursors for Nazarov Reagent

Author(s): H. Surya Prakash Rao, Shaik Rafi, K. Padmavathy.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 7 , 2008

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Abstract:

A facile, efficient and high-yielding two-step synthesis of 3-oxo-5-arylthiopentanoates - the precursors for Nazarov reagent - from low-cost bench top chemicals like thiophenols, acrylonitrile, zinc and ethyl bromoacetate via the Blaise reaction, is reported.

Keywords: Nazarov reagent, Blaise reaction, β-Keto ester

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Article Details

VOLUME: 5
ISSUE: 7
Year: 2008
Page: [527 - 529]
Pages: 3
DOI: 10.2174/157017808785982121
Price: $65

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