Synthesis of 5-(Carbohydrate-ethynyl)-2-deoxyuridine Derivatives

Author(s): Ruchun Yang, Haixin Ding, Yang Song, Weihong Xiao, Qiang Xiao, Jun Wu.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 7 , 2008

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Sonogashira reaction has been successfully applied to the synthesis of a series of 5-(carbohydrate-ethynyl)-2- deoxyuridines for the first time. The synthetic route is general, high-yielding and compatible with the readily removable protecting group.

Keywords: Sonogashira reaction, 5-iodo-2'-deoxyuridine, 2-propynyl β-D-glycosides, nucleosides derivatives, Palladium catalysis, cross coupling reaction

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Article Details

Year: 2008
Page: [518 - 521]
Pages: 4
DOI: 10.2174/157017808785982185
Price: $65

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