Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions

Author(s): Mei Xiao, Hongsong Yang, Suzane M. Klein, Christian M. Muenyi, William L. Stone, Yu L. Jiang.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 7 , 2008

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A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give tbutyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration.

Keywords: Anticancer drug, NCX 4040, design, synthesis, mild conditions, LNCaP cancer cell lines, prostate cancer

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Article Details

Year: 2008
Page: [510 - 513]
Pages: 4
DOI: 10.2174/157017808785982257
Price: $65

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