Discovery of New Therapeutic Targets by the Informational Spectrum Method

Author(s): Nevena Veljkovic , Sanja Glisic , Jelena Prljic , Vladimir Perovic , Maurizio Botta , Veljko Veljkovic .

Journal Name: Current Protein & Peptide Science

Volume 9 , Issue 5 , 2008

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Abstract:

The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of proteins, in identification of functional protein domains representing candidate therapeutic targets for drugs against human immunodeficiency virus (HIV)-1, anthrax, highly pathogenic influenza virus H5N1 and cardiovascular diseases.

Keywords: Bioinformatics, target, electron-ion interaction potential, informational spectrum method, H5N1, HIV-1, anthrax

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Article Details

VOLUME: 9
ISSUE: 5
Year: 2008
Page: [493 - 506]
Pages: 14
DOI: 10.2174/138920308785915245
Price: $58

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