Sesquiterpene Lactones and their Anti-Tumor Activity from the Flowers of Inula Britannica

Title: Sesquiterpene Lactones and their Anti-Tumor Activity from the Flowers of Inula Britannica

Volume: 5 Issue: 7

Author(s): Jin-Long Qi, Yan Fu, Xiao-Wei Shi, Yi-Bing Wu, Yun-Zhi Wang, Di-Qun Zhang and Qing-Wen Shi

Affiliation:

Keywords: 6β-O-isobutyrylbritannilactone, Sesquiterpene lactones, Inula Britannica, Anti-tumor activity, Anticancer

Abstract: A new sesquiterpene lactone, 6β-O-isobutyrylbritannilactone (5) and five known sesquiterpene lactones; britannilactone (1), 1-O-acetylbritannilactone (2), Hydroxy alantolactone (3), 8-epi-ivangustin (4) and 1,6-O,Odiacetylbritannilactone (6), were isolated from the flowers of Inula britannica. In the known sesquiterpene lactones, (3) and (4) were isolated for the first time from Inula britannica. The structures of these compounds were established unambiguously by UV, MS and a series of 1D and 2D NMR analyses. Compounds 3, 4, 5 and 6 exhibited significant cytotoxicity for tumor cells in vitro in bioassay.

Cite this article as:

Qi Jin-Long, Fu Yan, Shi Xiao-Wei, Wu Yi-Bing, Wang Yun-Zhi, Zhang Di-Qun and Shi Qing-Wen, Sesquiterpene Lactones and their Anti-Tumor Activity from the Flowers of Inula Britannica, Letters in Drug Design & Discovery 2008; 5 (7) . https://dx.doi.org/10.2174/157018008785909813