Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis, DNA-Binding Ability and Biological Activity of C8 Linked G1 Dendrimer-Pyrrolobenzodiazepine Conjugates as Anticancer Agents

Author(s): Ahmed Kamal, G. Balakishan, Rajender, K. Sreekanth, D. Rajasekhar Reddy, M. Kashi Reddy, Subrata Sen, Nisha Kurian, Aarti S. Juvekar, Surekha M. Zingde.

Abstract:

Some pyrrolo[2,1-c][1,4]benzodiazepine-G1 poly (aryl ether) dendrimer hybrids have been synthesized and evaluated for their DNA binding ability as well as anticancer activity. The linkage of dendrimer component significantly increased DNA binding ability and anticancer activity apart from the enhancement of their solubility, and taking part as a drug carrier.

Keywords: G1 Poly (aryl ether) dendrimer, Pyrrolobenzodiazepine, Piperazine, Lipophilicity, DNA-binding affinity and cytotoxicity

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Article Details

VOLUME: 5
ISSUE: 7
Year: 2008
Page: [424 - 432]
Pages: 9
DOI: 10.2174/157018008785909859
Price: $58