Login

Journal Image
Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 8
ISSUE: 11
DOI: 10.2174/138955708785909899      Price:  $58









Caspases: Structure-Guided Design of Drugs to Control Cell Death

img
Author(s): Irene T. Weber, Bin Fang and Johnson Agniswamy
Pages 1154-1162 (9)
Abstract:
The structures of caspases reveal the mechanism of binding for non-peptide and protein inhibitors, and have been applied in the design of agents that either inhibit or activate caspases to control cell death in diverse diseases. Decreased cell death is desirable for treatment of stroke, nerve crush injury, myocardial infarction, neuromuscular and neurodegenerative diseases and several non-peptide caspase inhibitors have been developed. In contrast, activation of cell death would be advantageous in cancer therapy, and the strategy is to block the binding of inhibitory proteins to caspases. Recent preclinical studies are described.
Keywords:
Cysteine protease, drug design, cell death, substrate recognition, apoptosis
Affiliation:
Department of Biology, Georgia State University, P.O. Box 4010, Atlanta, GA 30302, USA.