Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Octanol Water Partition Coefficient Determination for Model Steroids Using an HPLC Method

Author(s): Sara Zargar Shoshtari, Jingyuan Wen, Raid. G. Alany.

Abstract:

Applicability of HPLC based models for calculating partition coefficient (logP) of steroids was investigated. Retention time was used to calculate retention factor (logK), isocratic (CHIi) and gradient (CHIg) Chromatography Hydrophobicity Index. CHIi was shown to be an accurate logP predictor for selected steroids and as such offer an alternative to the shake flask method.

Keywords: Partition coefficient, Reversed phased liquid chromatography, Chromatographic Hydrophobicity Index (CHI), Lipophilicity

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2008
Page: [394 - 400]
Pages: 7
DOI: 10.2174/157018008785777333
Price: $58