Antimicrobial Activities of 7-Aminosterol Squalamine Analogues

Celine      Loncle; Chanaz      Salmi; Nicolas      Vidal; Yves      Letourneux; Jean   Michel   Brunel

Abstract

A series of new 7-aminosteroid derivatives were evaluated for their in vitro antimicrobial properties against human pathogens such as Gram positive bacteria. All the compounds present excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with MICs varying from 1.56 to 12.5 μg/mL. Moreover, all these considered derivatives possess MICs against Gram-negative Escherichia Coli bacteria (MIC varying from 2.5 to 10 μg/mL) making them particularly suitable for topical antibacterial use.

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Letters in Drug Design & Discovery

Title: Antimicrobial Activities of 7-Aminosterol Squalamine Analogues

Volume: 5 Issue: 6

Author(s): Celine Loncle, Chanaz Salmi, Nicolas Vidal, Yves Letourneux and Jean Michel Brunel

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Abstract: A series of new 7-aminosteroid derivatives were evaluated for their in vitro antimicrobial properties against human pathogens such as Gram positive bacteria. All the compounds present excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with MICs varying from 1.56 to 12.5 μg/mL. Moreover, all these considered derivatives possess MICs against Gram-negative Escherichia Coli bacteria (MIC varying from 2.5 to 10 μg/mL) making them particularly suitable for topical antibacterial use.

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Loncle Celine, Salmi Chanaz, Vidal Nicolas, Letourneux Yves and Brunel Michel Jean, Antimicrobial Activities of 7-Aminosterol Squalamine Analogues, Letters in Drug Design & Discovery 2008; 5 (6) . https://dx.doi.org/10.2174/157018008785777306