Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Antimicrobial Activities of 7-Aminosterol Squalamine Analogues

Author(s): Celine Loncle, Chanaz Salmi, Nicolas Vidal, Yves Letourneux, Jean Michel Brunel.

Abstract:

A series of new 7-aminosteroid derivatives were evaluated for their in vitro antimicrobial properties against human pathogens such as Gram positive bacteria. All the compounds present excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with MICs varying from 1.56 to 12.5 μg/mL. Moreover, all these considered derivatives possess MICs against Gram-negative Escherichia Coli bacteria (MIC varying from 2.5 to 10 μg/mL) making them particularly suitable for topical antibacterial use.

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2008
Page: [388 - 393]
Pages: 6
DOI: 10.2174/157018008785777306
Price: $58