A Preliminary Assessment of the Structure-Activity Relationship of Benzimidazole-Based Anti-Proliferative Agents
Leyte L. Winfield,
Dayle M. Smith,
Carmine S. Leggett.
PDK1 is pivotal in the development and progression of several cancers. A 3D pharmacophore was developed for pyrazole derivatives displaying anti-proliferative activity and PDK1 inhibition. The pharmacophore was utilized in the design of benzimidazole analogs. Our preliminary results indicate the pharmacophore should be useful in designing PDK1 inhibitors and anti-proliferative agents.
Keywords: 3D Pharmacophore, Benzimidazole, PDK1, Prostate cancer, SAR, Anti-proliferative
Rights & PermissionsPrintExport