Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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New Synthetic Chalcones: Cytotoxic Mannich Bases of 6-(4-Chlorocinnamoyl)-2(3H)-benzoxazolone

Author(s): O. Petrov, Y. Ivanova, G. Momekov, V. Kalcheva.

Abstract:

A number of Mannich bases were synthesized by a reaction between 6-(4-chlorocinnamoyl)-2(3H)-benzoxazolone, formaldehyde and secondary amines. The structures of the compounds were confirmed by elemental analysis, IR and 1H-NMR spectra. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations with IC50 values ranging between 1.4 and 30.9 μM.

Keywords: Chalcone, 2(3H)-Benzoxazolone, Mannich base, Cytotoxicity

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2008
Page: [358 - 361]
Pages: 4
DOI: 10.2174/157018008785777342
Price: $58