Biochemical and Structural Investigations of Bothropstoxin-II, a Myotoxic Asp49 Phospholipase A2 from Bothrops jararacussu Venom
Mario T. Murakami, Marco R. Lourenzoni, Emerson Z. Arruda, Marcelo A. Tomaz, Magno M. Vicoti, Jose R. B. Abrego, Paulo A. Melo and Raghuvir K. Arni
Affiliation: Department of Physics, IBILCE/UNESP, Cristovao Colombo 2265, Sao Jose do Rio Preto, SP, 15054-000, Brazil.
Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding.
Keywords: Phospholipases A2, suramin, pharmacological activities, structural studies
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