Biochemical and Structural Investigations of Bothropstoxin-II, a Myotoxic Asp49 Phospholipase A2 from Bothrops jararacussu Venom

Author(s): Mario T. Murakami, Marco R. Lourenzoni, Emerson Z. Arruda, Marcelo A. Tomaz, Magno M. Vicoti, Jose R. B. Abrego, Paulo A. Melo, Raghuvir K. Arni.

Journal Name: Protein & Peptide Letters

Volume 15 , Issue 9 , 2008

Abstract:

Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding.

Keywords: Phospholipases A2, suramin, pharmacological activities, structural studies

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Article Details

VOLUME: 15
ISSUE: 9
Year: 2008
Page: [1002 - 1008]
Pages: 7
DOI: 10.2174/092986608785849245
Price: $58

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