The present review brings a timeline of some of the major steps given throughout the years towards the development of our knowledge regarding the biology of the neutrophil. The contribution of early articles and their elementary biochemical approach is highlighted. The importance of the development of proteomic techniques is paralleled to the shift in neutrophil research towards high throughput molecular methods. As a last change of standpoint, the study of the neutrophil is presented integrated with other lifesciences technologies such as lipidomics, genomics and systems biology. The paper also brings a perspective/ tendency overview at the same time that it discusses some of the difficulties encountered in the research of the neutrophil.
Keywords: Neutrophil, proteome, two-dimensional electrophoresis, mass spectrometry
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