Current Women`s Health Reviews

John Yeh  
Harvard Medical School 
Department of Obstetrics and Gynecology
Massachusetts General Hospital
Boston, MA
USA

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Emerging Trends in Endometriosis Treatment - Review

Author(s): Warren B. Nothnick, Xuan Zhang.

Abstract:

Endometriosis is an enigmatic, debilitating disease which affects as many as 15% of all women of reproductive age and is characterized by pelvic pain and infertility. Current treatment regimes used to manage the disease do so by inducing a hypoestrogenic state. While the absence of circulating estrogen levels lead to a regression of the disease, this hypoestrogenism also induces many unpleasant side-effects. As such, these and other shortcomings of current drug therapies emphasize their limitations and the necessity for the development of novel endometriosis treatments. In this review, current therapies for medical management of endometriosis are discussed as are their shortcomings. Potential target areas which may be attractive alternatives to current therapies are also reviewed. Emphasis is placed upon the emerging research using TNF inhibitors, their potential benefits over current treatment regimes and the development of future potential therapeutic targets.

Keywords: Endometriosis, treatment, tumor necrosis factor-alpha, matrix metalloproteinase, aromatase, angiogenesis

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2008
Page: [188 - 199]
Pages: 12
DOI: 10.2174/157340408785821746
Price: $58