IL-17 and its Receptor Complex as Therapeutic Targets in Arthritis

Author(s): Myew-Ling Toh, Pierre Miossec.

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)

Volume 8 , Issue 3 , 2008

Abstract:

In addition to TNF and IL-1, IL-17 derived from Th17 cells is a leading cytokine target and has an established key role in adaptive and autoimmune disease such as rheumatoid arthritis (RA). A recent explosion in the literature in the last few years has lead to a renewal of interest in IL-17 as a key causative cytokine implicated in autoimmunity. This review will focus on IL-17 and its receptor as emerging therapeutic targets in RA.

Keywords: IL-17, Arthritis, TNF, cytokine, autoimmune disease, autoimmunity, therapeutic targets

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2008
Page: [247 - 251]
Pages: 5
DOI: 10.2174/187152208785748331
Price: $58