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Inflammation & Allergy-Drug Targets
(Formerly Current Drug Targets - Inflammation & Allergy)
ISSN (Print): 1871-5281
ISSN (Online): 2212-4055
VOLUME: 7
ISSUE: 3
DOI: 10.2174/187152808785748100      Price:  $58









Lead Compounds for Anti-inflammatory Drugs Isolated from the Plants of the Traditional Oriental Medicine in Korea

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Author(s): JangJa Hong, Kuk Hyun Shin, Soon Sung Lim, Jong Hwan Kwak, OkPyo Zee, Kenji Ishihara, Noriyasu Hirasawa, Toshio Seyama and Kazuo Ohuchi
Pages 195-202 (8)
Abstract:
Effects of compounds isolated from medicinal plants in Korea on prostaglandin E2 (PGE2) production in rat peritoneal macrophages were examined, and mechanism of action of the active constituents was analyzed. The active constituents were as follows; tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis, platycodin D isolated from the roots of Platycodon grandiflorum, imperatorin isolated from the roots of Angelica dahurica, and hyperin isolated from the roots of Acanthopanax chiisanensis. These compounds inhibit the induction of cyclooxygenase-2 (COX- 2), thus inhibiting PGE2 production. The chemically synthesized chalcone derivative, 2-hydroxy-4-methoxychalcone, also inhibits PGE2 production by suppressing COX-2 induction. In contrast, taiwanin C isolated from the roots of Acanthopanax chiisanensis inhibited PGE2 production by direct inhibition of COX-1 and COX-2.
Keywords:
Prostaglandin E2, cyclooxygenase-2, macrophage, tectorigenin, platycodin D, imperatorin, hyperin, 2'-hydroxy-4'-methoxychalcone, taiwanin C
Affiliation:
Laboratory of Life Sciences, Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan.