A Simple and High-Yield Route to N-9-purinyl-acetic Acid Derivatives Coupled with Amino Acids

Author(s): Marie-Emmanuelle Million, Sylvie Radix, Sebastien Marrot, Magali Imbert, Joelle Paris.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 6 , 2008

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A facile route to synthesize amide type N-9-purinyl-acetic acid derivatives both in guanine and hypoxanthine series is described. The regioselective alkylation of the 6-chloro-purine derivatives followed by their conversion into guanine or hypoxanthine nucleus in mild acidic conditions, are the key steps that allow the efficient preparation of compounds with an acetic function coupled with various amino acids.

Keywords: Purinyl-acetic acid derivatives, peptide coupling, hypoxanthine, guanine

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Article Details

Year: 2008
Page: [484 - 489]
Pages: 6
DOI: 10.2174/157017808785740408
Price: $65

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