TMSCl-NaI-MeCN Reagent Mediated Simple Two-Step Synthesis of Phenolic Benzosultams

Author(s): Rui Wang, Fang Fang, Long-Qian Tang, Zhao-Peng Liu.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 6 , 2008

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A novel simple two-step synthesis of phenolic benzosultams is first reported. o-Lithiation of N-Boc-otoluenesulfonamide followed by reaction with methoxybenzaldehydes gave carbinol sulfonamides, which were converted to the cyclic phenolic compounds via TMSCl/NaI/MeCN reagent mediated sequence involving N-deprotective cyclization and O-demethylation.

Keywords: Polyphenols, TMSCl/NaI/MeCN, cyclization, benzosultams, sulfonamides

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Article Details

Year: 2008
Page: [461 - 463]
Pages: 3
DOI: 10.2174/157017808785740426
Price: $65

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