Bi(OTf)3 as Mild, Efficient and Cost-Effective Catalyst for the Alkylation of N-Heterocycles with Epoxides

Author(s): Jhillu S. Yadav, Basi V. Subbareddy, Avvaru D. Krishna, Ailuri R. Reddy, Akkirala V. Narsaiah.

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 6 , 2008

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Epoxides undergo smooth ring opening with N-heterocyclic compounds such as indoles and pyrroles in the presence of a catalytic amount of bismuth triflate under mild conditions to produce C-alkylated indole and pyrrole derivatives in high yields with a high regioselectivity. Imidazole and benzotriazole affords N-alkylated products under identical conditions.

Keywords: Epoxides, bismuth compounds, N-heterocycles, tryptophol derivatives

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Article Details

Year: 2008
Page: [455 - 460]
Pages: 6
DOI: 10.2174/157017808785740453
Price: $65

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