Flavonoids: Cellular and Molecular Mechanism of Action in Glucose Homeostasis

Author(s): Luisa Helena Cazarolli, Leila Zanatta, Elga Heloisa Alberton, Maria Santos Reis Bonorino Figueiredo, Poliane Folador, Rosangela Guollo Damazio, Moacir Geraldo Pizzolatti, Fatima Regina Mena Barreto Silva.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 10 , 2008

Abstract:

The purpose of this review is to discuss the cellular and molecular mechanisms of action of flavonoids focusing on carbohydrate metabolism. The beneficial effects of flavonoids have been studied in relation to diabetes mellitus, either through their capacity to avoid glucose absorption or to improve glucose tolerance. Furthermore, flavonoids stimulate glucose uptake in peripheral tissues, regulate the activity and/or expression of the rate-limiting enzymes in the carbohydrate metabolism pathway and act per se as insulin secretagogues or insulin mimetics, probably, by influencing the pleiotropic mechanisms of insulin signaling, to ameliorate the diabetes status.

Keywords: Flavonoids, mechanism of action, glycemia, insulin, diabetes

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Article Details

VOLUME: 8
ISSUE: 10
Year: 2008
Page: [1032 - 1038]
Pages: 7
DOI: 10.2174/138955708785740580
Price: $58

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