Abstract
Ototoxic drugs, intense sound or age-related hearing loss recruit most of the apoptotic pathways, but also several additional enzymatic pathways which eventually result in cell death. Here, we discuss therapeutic strategies based on the inhibition of regulators or executors of apoptotic cell death pathways and on the use of antioxidants.
Keywords: Apoptosis, necrosis, cell death pathway, cochlea, therapeutic strategies, ototoxic drugs, intense sound, age-related hearing loss
Mini-Reviews in Medicinal Chemistry
Title: From Cochlear Cell Death Pathways To New Pharmacological Therapies
Volume: 8 Issue: 10
Author(s): Jing Wang and Jean-Luc Puel
Affiliation:
Keywords: Apoptosis, necrosis, cell death pathway, cochlea, therapeutic strategies, ototoxic drugs, intense sound, age-related hearing loss
Abstract: Ototoxic drugs, intense sound or age-related hearing loss recruit most of the apoptotic pathways, but also several additional enzymatic pathways which eventually result in cell death. Here, we discuss therapeutic strategies based on the inhibition of regulators or executors of apoptotic cell death pathways and on the use of antioxidants.
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Cite this article as:
Wang Jing and Puel Jean-Luc, From Cochlear Cell Death Pathways To New Pharmacological Therapies, Mini-Reviews in Medicinal Chemistry 2008; 8 (10) . https://dx.doi.org/10.2174/138955708785740599
DOI https://dx.doi.org/10.2174/138955708785740599 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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