Abstract
Different series of fluorescent agonists and antagonists have been developed and characterized for argininevasopressin and oxytocin G protein-coupled receptors. Both cyclic and linear peptide analogs of the neurohypophysial hormones are useful tools for investigating receptor localization and trafficking, analysing receptor structural organization, and developing new receptor-selective high-throughput ligand screening assays.
Keywords: Arginine-vasopressin, oxytocin, G protein-coupled receptor, structure-activity relationships, fluorescent peptide, fluorescence resonance energy transfer, fluorescence polarization, high-throughput screening assays
Mini-Reviews in Medicinal Chemistry
Title: Fluorescent Agonists and Antagonists for Vasopressin/Oxytocin G Protein-Coupled Receptors: Usefulness in Ligand Screening Assays and Receptor Studies
Volume: 8 Issue: 10
Author(s): B. Mouillac, M. Manning and T. Durroux
Affiliation:
Keywords: Arginine-vasopressin, oxytocin, G protein-coupled receptor, structure-activity relationships, fluorescent peptide, fluorescence resonance energy transfer, fluorescence polarization, high-throughput screening assays
Abstract: Different series of fluorescent agonists and antagonists have been developed and characterized for argininevasopressin and oxytocin G protein-coupled receptors. Both cyclic and linear peptide analogs of the neurohypophysial hormones are useful tools for investigating receptor localization and trafficking, analysing receptor structural organization, and developing new receptor-selective high-throughput ligand screening assays.
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Cite this article as:
Mouillac B., Manning M. and Durroux T., Fluorescent Agonists and Antagonists for Vasopressin/Oxytocin G Protein-Coupled Receptors: Usefulness in Ligand Screening Assays and Receptor Studies, Mini-Reviews in Medicinal Chemistry 2008; 8 (10) . https://dx.doi.org/10.2174/138955708785740607
DOI https://dx.doi.org/10.2174/138955708785740607 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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