Fluorescent Agonists and Antagonists for Vasopressin/Oxytocin G Protein-Coupled Receptors: Usefulness in Ligand Screening Assays and Receptor Studies

Author(s): B. Mouillac, M. Manning, T. Durroux.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 10 , 2008

Abstract:

Different series of fluorescent agonists and antagonists have been developed and characterized for argininevasopressin and oxytocin G protein-coupled receptors. Both cyclic and linear peptide analogs of the neurohypophysial hormones are useful tools for investigating receptor localization and trafficking, analysing receptor structural organization, and developing new receptor-selective high-throughput ligand screening assays.

Keywords: Arginine-vasopressin, oxytocin, G protein-coupled receptor, structure-activity relationships, fluorescent peptide, fluorescence resonance energy transfer, fluorescence polarization, high-throughput screening assays

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Article Details

VOLUME: 8
ISSUE: 10
Year: 2008
Page: [996 - 1005]
Pages: 10
DOI: 10.2174/138955708785740607
Price: $58

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