Dopamine D5 Receptors: A Challenge to Medicinal Chemists

Author(s): G. Giorgioni, A. Piergentili, S. Ruggieri, W. Quaglia.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 10 , 2008

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Due to the lack of highly selective dopamine D1 or D5 receptor ligands, only few data about activation or blocking of these receptor subtypes are available. The present review collects the available information about molecules with notable affinity for D5 receptor subtype with the purpose to help the researchers to design novel D5 selective ligands, whose discovery may enrich the knowledge about the physiological function of such a receptor, provide information about its topography, as well as lead to novel potential therapeutic tools.

Keywords: Dopamine receptor ligands, D1 subtype, D5 subtype, structure-activity relationship (SAR), pharmacophore

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Article Details

Year: 2008
Page: [976 - 995]
Pages: 20
DOI: 10.2174/138955708785740661
Price: $65

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