The Reactions Between HOCl and Differently Saturated Phospholipids: Physiological Relevance, Products and Methods of Evaluation

Author(s): Beate Fuchs, Celestina Schober, Grit Richter, Ariane Nimptsch, Rosmarie Suß, Jurgen Schiller.

Journal Name: Mini-Reviews in Organic Chemistry

Volume 5 , Issue 3 , 2008

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Abstract:

Phospholipids (PLs) are important constituents of cellular membranes. HOCl is a reactive oxygen species (ROS) generated under inflammatory conditions and capable of reacting with (a) the head group of PLs and (b) the olefinic groups of their fatty acyl residues under the preferred generation of chloramines and chlorohydrines, respectively. This review discusses these products, their stabilities and in vivo relevance. Additionally, important methods (spectroscopic as well as mass spectrometric techniques) to analyze these products are compared.

Keywords: HOCl, Saturated Phospholipids, reactive oxygen species (ROS), mass spectrometric techniques, phosphatidylcholine (PC)

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2008
Page: [254 - 261]
Pages: 8
DOI: 10.2174/157019308785161648
Price: $58