Macrocyclic Schiff bases form an important class of macrocyclic host systems, which are formed by self condensation of a diamine with a diformyl compound. Chiral modification of macrocyclic Schiff bases with different central cavity sizes were recently developed and explored. This mini-review will discuss some of the synthetic strategies, solid state crystal structures, and recent applications of different [n+n] chiral macrocyclic Schiff bases.
Keywords: Chiral [n+n] macrocycles, schiff bases, diastereomers, ligands, enantioselective synthesis
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