Role and Pharmacogenomics of TNF-α in Asthma

Author(s): Dimosthenis Lykouras, Fotis Sampsonas, Alexandros Kaparianos, Kiriakos Karkoulias, Kostas Spiropoulos.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 9 , 2008

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Abstract:

Asthma is a chronic heterogeneous inflammatory disease of the respiratory system in which numerous cytokines play a significant role. Among them TNF-α (tumour necrosis factor α), a proinflammatory cytokine, has a predominant role in orchestrating airway inflammation and affecting treatment outcome. In this review we attempt to summarize the involvement of TNF-α in the pathogenesis of asthma, illustrate variations of TNF-α gene that potentially influence asthma phenotype and highlight promising therapies by blocking the production of TNF-α or inhibiting its action. A cytokine specific target therapy seems to be very promising since agents that block TNF-α slow disease progression, suppress inflammation and in some cases induce remission of chronic inflammation.

Keywords: Asthma, TNF, inflammatory disease, chronic inflammation., chronic heterpgeneous disease

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Article Details

VOLUME: 8
ISSUE: 9
Year: 2008
Page: [934 - 942]
Pages: 9
DOI: 10.2174/138955708785132828
Price: $58

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