Azathioprine in Multiple Sclerosis

Author(s): Paolo Invernizz, Maria Donata Benedetti, Sarah Poli, Salvatore Monaco.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 9 , 2008

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Abstract:

Azathioprine is an immunosuppressive and steroid-sparing purine analogue, used in the treatment of several autoimmune diseases. In multiple sclerosis, available evidence suggests that oral azathioprine reduces relapse rates, provides a slight benefit on disability, and reduces new inflammatory lesions. Here, we focus on molecular mechanisms of Azathioprine and on its usefulness in multiple sclerosis.

Keywords: Azathioprine, multiple sclerosis, immunosuppression, thiopurine methyltransferase, tolerability, relapses, disability, immunomodulators

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Article Details

VOLUME: 8
ISSUE: 9
Year: 2008
Page: [919 - 926]
Pages: 8
DOI: 10.2174/138955708785132756
Price: $58

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