Apoptosis in Atherosclerosis: A Mini-Review

Author(s): Maria Karaflou, Irene Lambrinoudaki, George Christodoulakos.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 9 , 2008

Become EABM
Become Reviewer

Abstract:

Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.

Keywords: Atherosclerosis, apoptosis, pathogenesis

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 8
ISSUE: 9
Year: 2008
Page: [912 - 918]
Pages: 7
DOI: 10.2174/138955708785132765
Price: $58

Article Metrics

PDF: 8