Abstract
Glutathione Transferases (GSTs) are crucial enzymes in the cell detoxification process catalyzing the nucleophilic attack of glutathione (GSH) on toxic electrophilic substrates and producing a less dangerous compound. GSTs studies are of great importance since they have been implicated in the development of drug resistance in tumoral cells and are related to human diseases such as Parkinsons, Alzheimers, atherosclerois, liver cirrhosis, aging and cataract formation. In this review we start by providing an evolutionary perspective of the mammalian cytosolic GSTs known to date. Later on we focus on the more abundant classes alpha, mu and pi and their structure, catalysis, metabolic associated functions, drug resistance relation and inhibition methods. Finally, we introduce the recent insights on the GST class zeta from a metabolic perspective.
Keywords: Glutathione S-tranferase (GST), Glutathione (GSH), Glutathione S-transferase (GST) classes alpha, mu, pi and zeta, catalysis, metabolism of endogenous compounds, tumorogenesis, inhibition methods
Current Protein & Peptide Science
Title: Mammalian Cytosolic Glutathione Transferases
Volume: 9 Issue: 4
Author(s): Daniel F.A.R. Dourado, Pedro Alexandrino Fernandes and Maria Joao Ramos
Affiliation:
Keywords: Glutathione S-tranferase (GST), Glutathione (GSH), Glutathione S-transferase (GST) classes alpha, mu, pi and zeta, catalysis, metabolism of endogenous compounds, tumorogenesis, inhibition methods
Abstract: Glutathione Transferases (GSTs) are crucial enzymes in the cell detoxification process catalyzing the nucleophilic attack of glutathione (GSH) on toxic electrophilic substrates and producing a less dangerous compound. GSTs studies are of great importance since they have been implicated in the development of drug resistance in tumoral cells and are related to human diseases such as Parkinsons, Alzheimers, atherosclerois, liver cirrhosis, aging and cataract formation. In this review we start by providing an evolutionary perspective of the mammalian cytosolic GSTs known to date. Later on we focus on the more abundant classes alpha, mu and pi and their structure, catalysis, metabolic associated functions, drug resistance relation and inhibition methods. Finally, we introduce the recent insights on the GST class zeta from a metabolic perspective.
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Cite this article as:
Dourado F.A.R. Daniel, Fernandes Alexandrino Pedro and Ramos Joao Maria, Mammalian Cytosolic Glutathione Transferases, Current Protein & Peptide Science 2008; 9 (4) . https://dx.doi.org/10.2174/138920308785132677
DOI https://dx.doi.org/10.2174/138920308785132677 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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