Clinico-Pathologic Function of Cerebral ABC Transporters – Implications for the Pathogenesis of Alzheimers Disease
Jens Pahnke, Olaf Wolkenhauer, Markus Krohn and Lary C. Walker
Affiliation: University of Rostock, Department of Neurology, Neurodegeneration Research Laboratory (NRL), Gehlsheimer Str. 20, 18147 Rostock, Germany.
In recent years it has become evident that ABC transporters fulfill important barrier functions in normal organs and during disease processes. Most importantly, resistance to drugs in cancer cells led to intense oncological and pharmacological investigations in which researchers were able to highlight important pharmacological interactions of chemotherapeuticals with ABC transporter function. Recently, the development of neurodegenerative diseases and the maintenance of neuronal stem cells have been linked to the activity of ABC transporters. Here, we summarize findings from cell culture experiments, animal models and studies of patients with Alzheimers disease. Furthermore, we discuss pharmacological interactions and computational methods for risk assessment.
Keywords: ABC transporter, Alzheimer's disease, neurodegeneration, MDR1, MRP1, BCRP, systems biology, dementia, Abeta, blood-brain barrier
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