Current Alzheimer Research

Debomoy K. Lahiri  
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202


Structural Changes in Alzheimers Disease Brain Microvessels

Author(s): Alexander Christov, J. Ottman, L. Hamdheydari and Paula Grammas

Affiliation: Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street Stop 9424, Lubbock, Texas 79430, USA.


Brain microvascular alterations are thought to contribute to the development of stroke and dementia. Structural changes in capillaries of elderly patients correlate positively with advanced age and dementia. The objective of this study is to use laser-induced fluorescence spectroscopy to compare structural (collagen content) and functional (apoptosis) parameters in brain tissues and isolated vessels of AD patients to age-matched controls. Our results show significantly higher fluorescent labeling for apoptosis in AD vessels compared to controls. Also, there is significantly higher autofluorescence (reflecting levels of collagen and other proteins that autofluoresce) in AD brain and vessels compared to controls. Western blot analysis of collagen subtypes shows elevated type I and type III and reduced type IV levels in AD vessels. These data demonstrate that changes in the amount and type of collagen occur in AD brain and suggest that cerebral vessel injury is part of AD pathology.

Keywords: Alzheimer's, autofluorescence, collagen, apoptosis, resistance vessels, cerebrovascular

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Page: [392 - 395]
Pages: 4
DOI: 10.2174/156720508785132334
Price: $58