Abstract
Brain microvascular alterations are thought to contribute to the development of stroke and dementia. Structural changes in capillaries of elderly patients correlate positively with advanced age and dementia. The objective of this study is to use laser-induced fluorescence spectroscopy to compare structural (collagen content) and functional (apoptosis) parameters in brain tissues and isolated vessels of AD patients to age-matched controls. Our results show significantly higher fluorescent labeling for apoptosis in AD vessels compared to controls. Also, there is significantly higher autofluorescence (reflecting levels of collagen and other proteins that autofluoresce) in AD brain and vessels compared to controls. Western blot analysis of collagen subtypes shows elevated type I and type III and reduced type IV levels in AD vessels. These data demonstrate that changes in the amount and type of collagen occur in AD brain and suggest that cerebral vessel injury is part of AD pathology.
Keywords: Alzheimer's, autofluorescence, collagen, apoptosis, resistance vessels, cerebrovascular
Current Alzheimer Research
Title: Structural Changes in Alzheimers Disease Brain Microvessels
Volume: 5 Issue: 4
Author(s): Alexander Christov, J. Ottman, L. Hamdheydari and Paula Grammas
Affiliation:
Keywords: Alzheimer's, autofluorescence, collagen, apoptosis, resistance vessels, cerebrovascular
Abstract: Brain microvascular alterations are thought to contribute to the development of stroke and dementia. Structural changes in capillaries of elderly patients correlate positively with advanced age and dementia. The objective of this study is to use laser-induced fluorescence spectroscopy to compare structural (collagen content) and functional (apoptosis) parameters in brain tissues and isolated vessels of AD patients to age-matched controls. Our results show significantly higher fluorescent labeling for apoptosis in AD vessels compared to controls. Also, there is significantly higher autofluorescence (reflecting levels of collagen and other proteins that autofluoresce) in AD brain and vessels compared to controls. Western blot analysis of collagen subtypes shows elevated type I and type III and reduced type IV levels in AD vessels. These data demonstrate that changes in the amount and type of collagen occur in AD brain and suggest that cerebral vessel injury is part of AD pathology.
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Cite this article as:
Christov Alexander, Ottman J., Hamdheydari L. and Grammas Paula, Structural Changes in Alzheimers Disease Brain Microvessels, Current Alzheimer Research 2008; 5 (4) . https://dx.doi.org/10.2174/156720508785132334
DOI https://dx.doi.org/10.2174/156720508785132334 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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