From Dual Binding Site Acetylcholinesterase Inhibitors to Multi-Target-Directed Ligands (MTDLs): A Step Forward in the Treatment of Alzheimers Disease

Author(s): Maria Laura Bolognesi, Anna Minarini, Michela Rosini, Vincenzo Tumiatti, Carlo Melchiorre.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 10 , 2008

Abstract:

Alzheimers disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs. Recently, however, basis for a therapeutic strategy based on multi-target-directed ligands has been formed. In this context, dual binding site acetylcholinesterase inhibitors represent a suitable starting point. The rational modification of their structures to provide them with additional biological properties has emerged as a successful approach.

Keywords: Dimeric compounds, bivalent ligands, multimodal therapeutics, multifunctional compounds, multifactorial diseases

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Article Details

VOLUME: 8
ISSUE: 10
Year: 2008
Page: [960 - 967]
Pages: 8
DOI: 10.2174/138955708785740652
Price: $58

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