Current Organic Synthesis

L.-N. He
Nankai University
Tianjin
P.R. China

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Enzymatic Synthesis of Plant Polyketides

Author(s): Shepo Shi, Hiroyuki Morita, Kiyofumi Wanibuchi, Yuusuke Mizuuchi, Hiroshi Noguchi, Ikuro Abe.

Abstract:

The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.

Keywords: Type III polyketide synthase, enzymatic synthesis, precursor-directed biosynthesis, structure-based engineered biosynthesis, combinatorial biosynthesis

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2008
Page: [250 - 266]
Pages: 17
DOI: 10.2174/157017908785133410
Price: $58