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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Enzymatic Synthesis of Plant Polyketides

Author(s): Shepo Shi, Hiroyuki Morita, Kiyofumi Wanibuchi, Yuusuke Mizuuchi, Hiroshi Noguchi and Ikuro Abe

Volume 5, Issue 3, 2008

Page: [250 - 266] Pages: 17

DOI: 10.2174/157017908785133410

Price: $65

Abstract

The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.

Keywords: Type III polyketide synthase, enzymatic synthesis, precursor-directed biosynthesis, structure-based engineered biosynthesis, combinatorial biosynthesis


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