Differential Expression of Genes in Obesity and Type 2 Diabetes Mellitus
Allam Appa Rao.
Both obesity and type 2 diabetes mellitus are common. In a gene expression profile study, it was noted that genes concerned with carbohydrate, lipid and amino acid metabolism, and signal transduction pathways are upregulated, while genes involved in cell adhesion, cytokine-cytokine receptor interaction, insulin signaling, immune system pathways, and inflammatory pathway are differentially expressed both in obesity and type 2 diabetes.
Keywords: obesity, type 2 diabetes mellitus, metabolism, cytokine-cytokine receptor interaction, immune system pathways, inflammatory pathway, Carbon reactive protein (CRP)
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