Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues

Title: Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues

Volume: 5 Issue: 5

Author(s): Yushi Chi, Huibin Zhang, Jinpei Zhou, Wenlong Huang and Shuaijian Ni

Affiliation:

Keywords: Microwave, GLP-1, solid phase, peptide

Abstract: Gly8-GLP-1 (7∼36) amide and Exendin- 4, analogues of Glucagon-like peptide-1 (GLP-1), were synthesized rapidly and efficiently on rink amide MBHA resin under microwave irradiation, using Fmoc/tBu orthogonal protection strategy. The results showed that the synthesis of the medium- to large-length peptides was greatly improved in the reaction time and the purity of crude product with the use of microwave irradiation.

Cite this article as:

Chi Yushi, Zhang Huibin, Zhou Jinpei, Huang Wenlong and Ni Shuaijian, Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues, Letters in Organic Chemistry 2008; 5 (5) . https://dx.doi.org/10.2174/157017808784872061