Discovery of AX8312, an N-alkyl-Gly-boro-Pro Derivative that Accelerates Recovery from Neutropenia in the Mouse
Emme C.K. Lin,
Kevin R. Shreder,
Melissa C. Zhang,
Melissa S. Wong,
John W. Kozarich.
A screen of N-alkyl-Gly-boro-Pro DPP inhibitors using an acute murine model revealed that N-adamantyl and N-cycloalkyl groups greater in size than cyclobutyl significantly induced G-CSF. Treatment of neutropenic mice with the most efficacious compound, AX8312 (N-(1-adamantyl)-Gly-boro-Pro), resulted in a faster and greater neutrophil recovery versus vehicle-treated mice.
Keywords: N-alkyl-Gly-boro-Pro, G-CSF, Neutropenia, Cytokine, AX8312
Rights & PermissionsPrintExport