Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

Back

Structure-Activity Relationship Study of 8-amino-2,8-dideoxy-β -KDO, a Potent CMP-KDO Synthetase Inhibitor

Author(s): Hayamitsu Adachi, Ken-Ichiro Kondo, Fukiko Kojima, Yoji Umezawa, Keiko Ishino, Hotta Kunimoto, Yoshio Nishimura, Yuzuru Akamatsu.

Abstract:

8-Amino-2,8-dideoxy-β-KDO is a well-known inhibitor of CMP-KDO synthetase involved in the biosynthesis of lipopolysaccharide (LPS), an essential component of the outer membrane of gram-negative bacteria. Chemical modification of the hydroxyl groups of 8-amino-2,8-dideoxy- β-KDO proved that they play a crucial role in CMP-KDO synthetase inhibition.

Keywords: Gram-negative bacteria, Lipopolysaccharide (LPS), CMP-KDO synthetase inhibitor

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 5
ISSUE: 5
Year: 2008
Page: [336 - 339]
Pages: 4
DOI: 10.2174/157018008784912117
Price: $58