Abstract
8-Amino-2,8-dideoxy-β-KDO is a well-known inhibitor of CMP-KDO synthetase involved in the biosynthesis of lipopolysaccharide (LPS), an essential component of the outer membrane of gram-negative bacteria. Chemical modification of the hydroxyl groups of 8-amino-2,8-dideoxy- β-KDO proved that they play a crucial role in CMP-KDO synthetase inhibition.
Keywords: Gram-negative bacteria, Lipopolysaccharide (LPS), CMP-KDO synthetase inhibitor
Letters in Drug Design & Discovery
Title: Structure-Activity Relationship Study of 8-amino-2,8-dideoxy-β -KDO, a Potent CMP-KDO Synthetase Inhibitor
Volume: 5 Issue: 5
Author(s): Hayamitsu Adachi, Ken-Ichiro Kondo, Fukiko Kojima, Yoji Umezawa, Keiko Ishino, Hotta Kunimoto, Yoshio Nishimura and Yuzuru Akamatsu
Affiliation:
Keywords: Gram-negative bacteria, Lipopolysaccharide (LPS), CMP-KDO synthetase inhibitor
Abstract: 8-Amino-2,8-dideoxy-β-KDO is a well-known inhibitor of CMP-KDO synthetase involved in the biosynthesis of lipopolysaccharide (LPS), an essential component of the outer membrane of gram-negative bacteria. Chemical modification of the hydroxyl groups of 8-amino-2,8-dideoxy- β-KDO proved that they play a crucial role in CMP-KDO synthetase inhibition.
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Cite this article as:
Adachi Hayamitsu, Kondo Ken-Ichiro, Kojima Fukiko, Umezawa Yoji, Ishino Keiko, Kunimoto Hotta, Nishimura Yoshio and Akamatsu Yuzuru, Structure-Activity Relationship Study of 8-amino-2,8-dideoxy-β -KDO, a Potent CMP-KDO Synthetase Inhibitor, Letters in Drug Design & Discovery 2008; 5 (5) . https://dx.doi.org/10.2174/157018008784912117
DOI https://dx.doi.org/10.2174/157018008784912117 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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