Nociceptin/Orphanin FQ Peptide Receptor as a Therapeutic Target for Obesity

Author(s): Magdalena J. Przydzial, Lora K. Heisler.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 8 , 2008

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Abstract:

Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a candidate target for novel therapeutics for a range of conditions, including obesity. This article reviews recent advances in understanding of N/OFQs involvement in the regulation of food intake and appraises current developments in the rational design of antagonists aimed at the NOP receptor.

Keywords: Nociceptin/orphanin FQ, N/OFQ, nociceptin/orphanin FQ peptide (NOP) receptor, opioid receptor like-1 (ORL-1), opioid receptor-4 (OP4), kappa-type 3 opioid receptor (KOR-3), rat opioid receptor-C (ROR-C), obesity, food intake

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Article Details

VOLUME: 8
ISSUE: 8
Year: 2008
Page: [796 - 811]
Pages: 16
DOI: 10.2174/138955708784912139
Price: $58

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