Preclinical Study of New TB Drugs and Drug Combinations in Mouse Models

Author(s): Boris V. Nikonenko, Katherine A. Sacksteder, Sam Hundert, Leo Einck, Carol A. Nacy.

Journal Name: Recent Patents on Anti-Infective Drug Discovery

Volume 3 , Issue 2 , 2008

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Abstract:

Tuberculosis (TB) remains one of the leading infectious killers in the world. New anti-TB drugs and more effective drug combinations are urgently needed, particularly given the increasing incidence of drug-resistant TB and HIV-TB co-infection. This review describes the available mouse models of TB and describes their utility in the evaluation of new TB drug candidates and in the evaluation of the efficacy of new TB drug combinations. Some of the most recent patents on promising TB drug-candidates are also mentioned here.

Keywords: Tuberculosis, drugs, mouse model

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2008
Page: [102 - 116]
Pages: 15
DOI: 10.2174/157489108784746579
Price: $58

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